Arizona hosts San Francisco in Week 3 with a crowded injury report. Will Johnson DNP groin; Melton limited with a knee; Beachum, Hernandez, Paris Johnson Jr, Reiman, Simon and Stills limited or resting concerns; Jordan James back to full participation with a finger issue. The Cardinals eye a 3-0 start while juggling depth and playmakers.

San Francisco faces a similar test with eight DNPs on the list but Brock Purdy back in limited action as he finishes toe and shoulder rehab. With Nick Bosa resting and Christian McCaffrey dealing with a calf/rest, Kyle Shanahan will lean on creative wrinkles. Kyler Murray notes Levi’s Stadium vibe as a factor in this NFC West clash.

Trey Benson is emerging in Arizona, with 39% of the RB snaps and 11 carries for 83 yards plus 5 receptions on 7 targets through two games. If James Conner misses time, Benson could become a league-winner and should be added in all leagues ahead of Week 3. Cam Skattebo has seized the Giants’ short-yardage and early-down work, logging 51% of RB snaps in Week 2 and delivering 11 carries for 45 yards, a rushing TD, and 2 receptions. Kayshon Boutte has become Maye’s top target in New England, flashing big-play upside after Week 1’s 103-yard performance and remaining on the field for most snaps, making him a solid high-floor flex.

Expect the backfields to stay dynamic, with Benson offering immediate Week 3 value, Skattebo holding RB2 upside if the Giants’ offense improves, and Boutte continuing to hold a meaningful role in NE’s passing game. If you need Week 3 stability with ceiling, these three are prime targets on the waiver wire.

Week 3 brings Seattle as 7.5-point favorites at home against New Orleans, but injuries to Devon Witherspoon and Nick Emmanwori could blunt Seattle’s secondary edge. Spencer Rattler and the Saints offense have found traction, and the SportsLine model assigns a 38% upset chance for New Orleans—a surprisingly credible figure for a road test. The model’s Week 3 survivor pick diverges from Seattle, suggesting a one-score outcome with Seattle at about 62% win probability.

The slate features seven 5+ point spreads, including Dolphins-Bills, Packers-Browns, Falcons-Panthers, Jets-Bucs, Saints-Seahawks, Chiefs-Giants, and Lions-Ravens, underscoring how survivor players will chase value. The model touts a long, earned track record (10,000 simulations, 37-17 on top picks since 2024) and is the guiding beacon for those locking Week 3 picks, with promos noted for new users.

Marvin Harrison Jr. has just 11 targets through two games for Arizona, catching 2 for 27 in the latest winless struggle against Carolina after a 6-catch, 71-yard TD opener vs New Orleans. Kyler Murray nudges expectations with a candid take on target distribution—some days 10 looks, other days three, and that one football is shared by a lot. Harrison sits amid a rookie WR class with more early volume, while Arizona faces a Week 3 test as a 2.5-point underdog to San Francisco, making rest-of-season fantasy math intriguing and fluid.